Macedonia Intercity Coache Station is linked with all main road axes of Thessaloniki which are:
From the east:
- Egnadia Rd - Monastiri
- Tsimiski - Polytechniou - New Western Entrance.
- Giannitson - Giannitson Extension
- 26th October - New Western Entrance.
Form the west:
- Lagkada - Karaoli Dimitriou - Leoforos Dendropotamou - Menemeni Flyover
- Stavroupoli Flyover - ring road - Thessaloniki - Athens National Rd Crossing - New western entrance.
- Nea Ionia - Nea Monastiriou.